However, the higher risk of men was not observed when assessing the population without a previous history of ulceration or amputation. A prospective, but possibly underpowered, cohort study testing a priori for sex interactions states that women tend to consume more sugar, although high glycemic index diets seem to increase abdominal fat, particularly in sedentary women in contrast to sedentary men 123124. In another population-based sample of older people, T2DM also exerted greater impact on the risk of geriatric conditions in women than in men 337. Also the bidirectional modulation of glucose and lipid homeostasis by sex hormones and their receptor activation in central and peripheral targets in both sexes are influenced by estrogens and androgens 161765— 69. Maternal high-fat diet HFD in mice was reported to cause sex differences in glucose metabolism in offspring 145. Males tend to suffer more often of heart failure at younger age due to CVD. These are mediated through selective ERα activation under normoglycemic conditions.
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